Magnolia Regional Medical Center (MRMC) is a 501c3 non-profit Acute Care hospital that has been in continuous operation since 1939 and is licensed to operate 49 beds. In February 2010, a new facility replaced the original 1939 building and additions. The hospital continues to serve a diverse population in Columbia County and a large part of Southwest Arkansas.

MRMC features a 24/7 Emergency Department, surgical services, full laboratory and respiratory services, and advanced imaging. In addition, MRMC owns and operates three clinics: Magnolia Family Medical Clinic, MRMC Orthopedic Clinic, and MRMC General Surgery Clinic.